The assembly polypeptide 2 (AP2) complex is a key player in clathrin-mediated endocytosis (CME); it recruits clathrin to membranes, promotes the polymerization of clathrin into clathrin-coated pits ...

To allow substances such as neurotransmitters, nutrients, and even viruses to enter our cells, they are enclosed in vesicles at the cell membrane and transported into the cell interior. This transport ...

One characteristic linking members of the synaptotagmin family to endocytosis is their ability to bind the heterotetrameric AP2 complex via their C2B domain. By using CD4/synaptotagmin 1 chimeras, we ...