Nature

Comparison of primary analysis strategies of randomized controlled trials with multiple endpoints with application to kidney transplantation

Relying on a single primary endpoint in randomized controlled trials (RCTs) is often infeasible, for example due to rare or heterogeneous events. Regulatory guidance therefore allows multiple ...
Nature

Incorporating genetic data improves target trial emulations and informs the use of polygenic scores in randomized controlled trial design

When they are available, randomized controlled trials (RCTs) are the gold standard to evaluate the comparative efficacy and safety of medical interventions 1. Randomization ensures that the ...