Nature

Single-case experimental designs: the importance of randomization and replication

Single-case experimental designs (SCEDs) involve repeat measurements of the dependent variable under different experimental conditions within a single case, for example, a patient or a classroom 1.
Nature

Challenges in interpreting Mendelian randomization studies with a disease as the exposure: Using COVID-19 liability studies as an exemplar

Mendelian randomization (MR) studies using diseases as exposures are increasingly prevalent although any observed associations do not necessarily imply effect of diseases. To illustrate this challenge ...
ascopubs.org

Bayesian Adaptive Randomization: Full of Promise With a Helping of Caution

Poly(ADP-ribose) Polymerase Inhibitor Combinations in First-Line Metastatic Castration-Resistant Prostate Cancer: Increasing Toxicity With Unclear Benefits In the article that accompanies this ...