As the world tackles the COVID-19 pandemic, other widespread infectious diseases, including tuberculosis (TB), take their toll on humans, and those with TB are more likely to die from COVID-19 ...

Adenosine triphosphate (ATP), the fuel of life, is produced in inner membranes of the mitochondria of eukaryotic cells by an embedded molecular machine with a rotary action, called ATP synthase.

The c-ring is formed by two staggered, concentric rings of 15 helices, resulting in a clockwise vorticity when viewed from the cytoplasm. Both helices of one c subunit are connected by a loop on the ...

1 Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa, (CSIC-UAM), Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) ISCIII, Instituto de Investigación ...

Within the structurally-confined internal aqueous cavity of the F1-motor of ATP synthase, function results from free energy changes that shift the balance between interfacial charge hydration and ...

The occupancy of the central cavity of the membrane-embedded c ring of the ATP synthase of Escherichia coli was investigated with a photo-cross-linking approach. Single cysteine mutants were created ...

The chemical ATP, adenosine triphosphate, is the fuel that powers all life. Despite ATP's central role, the structure of the enzyme generating ATP, F1Fo-ATP synthase, in mammals, including humans, has ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Vesicular transport is a means of ...

eLife posts the editorial decision letter and author response on a selection of the published articles (subject to the approval of the authors). An edited version of the letter sent to the authors ...

Scientists have solved the structure of mitochondrial ATP synthase, an enzyme that makes ATP, adenosine triphosphate, the major energy source of cells. A team of scientists headed by Rosalind Franklin ...