Calcium's Role in Unveiling the Active Sites: In a resting muscle, the myosin-binding sites on actin are blocked by a protein complex called tropomyosin. Tropomyosin is a long, rod-shaped molecule ...
Vascular disease-causing mutation R258C in ACTA2 disrupts actin dynamics and interaction with myosin
Point mutations in vascular smooth muscle α-actin (SM α-actin), encoded by the gene ACTA2, are the most prevalent cause of familial thoracic aortic aneurysms and dissections (TAAD). Here, we provide ...
Skeletal and heart muscles contract and relax upon sliding of parallel filaments of the proteins myosin and actin. Nebulin, another long slender protein, which is present only in skeletal muscle, ...
This is a preview. Log in through your library . Abstract The organization of actin in mouse neuroblastoma and chicken dorsal root ganglion (DRG) nerve cells was investigated by means of a variety of ...
The standard textbook model of muscle contraction includes only two main players, the filaments actin and myosin, which slide past each other, causing the sarcomere—the basic unit of muscle tissue—to ...
Biomolecular condensates are distinct molecular communities made of DNA, RNA and proteins that “condense” molecules to key locations inside cells. Intense efforts have focused on uncovering the ...
It was 1975, and Thomas Stossel and John Hartwig were baffled by the "ugly precipitate" in the bottom of their test tube. Eager young biologists, the Harvard friends had set out to solve the mystery ...
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