Psoriasis is one of the most common chronic inflammatory skin diseases, affecting ~2% of the population. The lack of characterization of the pathogenesis of psoriasis has hindered efficient clinical ...

Introduction Critically ill patients are highly susceptible to nosocomial infections including ventilator-associated pneumonia. Susceptibility to nosocomial infection is heavily influenced by ...

Activation of the complement system through the alternative pathway is necessary for the development of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in animal models C5a has ...

Coronavirus disease-2019 (COVID-19) was declared as a pandemic by WHO in March 2020. SARS-CoV-2 causes a wide range of illness from asymptomatic to life-threatening. There is an essential need to ...

J Carvelliたちは今回、補体C5a–C5aRシグナル伝達軸が新型コロナウイルス感染症（COVID-19）患者の急性肺障害や急性呼吸窮迫症候群を誘導する炎症回路において役割を持つことを支持する知見を報告している。COVID-19患者では、血漿中のC5aレベルが疾患の重症度 ...

Please provide your email address to receive an email when new articles are posted on . Targeting the complement pathway using a C5a agonist may be a “game changer” in anti-neutrophil cytoplasmic ...

Center for Computational Biology, Department of Biochemistry and Molecular Biophysics, and Departments of Medicine and of Molecular Biology and Pharmacology, Washington University Medical School, St.