The order of cancer-driving mutations—genetic changes—plays an important role in whether tumors in the intestine can develop, ...

Scientists have identified nine new genes that drive the development of breast cancer, taking the tally associated with this type of cancer to 40. The study, led by the Wellcome Trust Sanger Institute ...

A closeup look at colibactin’s structure reveals chemical motifs that guide its mutation-wreaking “warheads” to specific stretches of DNA.

The difference between hereditary (germline) and acquired (somatic) gene mutations in cancer can lead to much confusion. This is especially true if you’re hearing about genetic testing for a genetic ...

New research published in Nature Communications has linked a normal cellular process to an accumulation of DNA mutations in ...

Comprehensive maps of mutations in healthy and diseased gastric tissue give clues about how cancer arises and could inform early-detection strategies. Read the paper: The somatic mutation landscape of ...

TP53 mutations are crucial in cancer development and treatment response, influenced by genetic and environmental factors. In CLL and AML, TP53 serves as a significant prognostic marker, affecting ...

Most cancer genome studies have focused on mutations in the tumor itself and how such gene variants allow a tumor to grow unchecked. A new study, led by researchers at Washington University School of ...

Dr. Marwan G. Fakih explains that KRAS mutations, found in 45% of patients with colorectal cancer, include the rare KRAS G12C mutation, leading to Lumakras approval. According to the National Cancer ...

A man treated for blood cancer has stayed HIV-free for seven years after a stem-cell transplant, even without the CCR5 ...

The deadliest cancers just met their match. A revolutionary cancer vaccine prevents the devastating relapses that have made KRAS-mutated tumors nearly impossible to cure, offering genuine hope to ...