The results uncover a notable parallel between the innate and adaptive immune systems. Whereas DNA deamination targeted to endogenous immunoglobulin loci is used to trigger the diversification of ...

Figure 1: Processive AID-catalysed C deamination on ssDNA recapitulates SHM hotspots and clonal mutational heterogeneity. Despite the occurrence of multiple mutations on a single DNA strand, the ...

Activation-induced deaminase (AID), a member of the larger AID/APOBEC family, is the key catalyst in initiating antibody somatic hypermutation and class-switch recombination. The DNA deamination model ...

Extracellular adenosine deamination by ADGF generates ammonia that directs tip organizer development, revealing a conserved metabolic mechanism linking nucleotide turnover to developmental regulation.

We report here a reaction that selectively deaminates primary amines and anilines under mild conditions and with remarkable functional group tolerance including a range of pharmaceutical compounds, ...

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is subjected to the host’s deamination system that includes the cytidine-to-uridine (C-to-U) deamination by apolipoprotein B messenger ...

Human APOBEC3G (A3G) is an antiviral factor that inactivates HIV. The C-terminal domain of A3G (A3G-CTD) deaminates cytosines into uracils within single-stranded DNA (ssDNA), which is ...

Departamento de Ingeniería Química y Química Física, Universidad de Extremadura, Badajoz, Spain The nitrogenous bases: adenine, guanine, cytosine, thymine, and uracil can be associate to form ...