The universally conserved enzyme CTP synthase (CTPS) forms filaments in bacteria and eukaryotes. In bacteria, polymerization inhibits CTPS activity and is required for nucleotide homeostasis. Here we ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 82, No. 8 (Apr. 15, 1985), pp. 2272-2276 (5 pages) We have replaced the glutamic acid-165 at the active site of ...

A research team believes it has solved a long-standing controversy in the field of bioinorganic chemistry about the identity and location of metal atoms in a key methane-oxidizing metalloenzyme ...

Different enzymes contain up to 20 different amino acids linked together to form a chain which then folds into the globular enzyme shape. Enzymes have active sites which only match specific substrates ...

Lys-48-linked polyubiquitination regulates a variety of cellular processes by targeting ubiquitinated proteins to the proteasome for degradation. Although polyubiquitination had been presumed to occur ...

All metabolic pathways have to be regulated and controlled to stop the build-up of an end product that isn’t needed. The cell can control a metabolic pathway by the presence or absence of a particular ...