Infection by Mycobacterium tuberculosis kills 1.5 million people worldwide every year. Antibiotics to treat TB exist, but in recent years, multi-drug resistant (MDR), extensively drug-resistant (XDR) ...

TMC207 is a first-in-class anti-TB diarylquinoline (also named R207910 or the 'J' compound) with activity against drug-sensitive and drug-resistant TB. TMC207 inhibits the proton pump of mycobacterial ...

An inexpensive, over-the-counter pain reliever can kill the bacteria that cause tuberculosis (TB)—even the drug-resistant varieties—according to a new study published online in the Proceedings of the ...

The bedaquiline–pretomanid–linezolid regimen has been reported to have 90% efficacy against highly drug-resistant tuberculosis, but the incidence of adverse events with 1200 mg of linezolid daily has ...

Cases of tuberculosis (TB) — an illness that kills more people than any other infectious disease — rose in the U.S. during 2022, per the Centers for Disease Control and Prevention (CDC). And some ...

The drugs, sutezolid and delpazolid, have demonstrated strong antimicrobial activity and a notably better safety profile compared to linezolid, with potential to replace this current cornerstone in ...

Tuberculosis (TB) is the world’s deadliest infectious disease. In 2023, about 10.8 million people contracted TB, and 1.25 million people died from it, according to the World Health Organization.