A major study published in this month's issue of Lancet Neurology, led by researchers at UCL's Institute of Neurology and funded by the EU-Framework 7 programme, provides the first in-vivo human ...

To investigate whether the amlodipine derivatives, CJX1 and CJX2, have a modulative effect on P-glycoprotein (P-gp) function in rat brain microvessel endothelial cells (RBMEC). Isolated RBMEC were ...

To investigate the modulatory effect of CJZ3, a lomerizine derivative, on P-glycoprotein (P-gp) function in rat brain microvessel endothelial cells (RBMEC). RBMEC were isolated and cultured in ...

Multidrug resistance (MDR) seriously limits the clinical application of chemotherapy. A mechanism underlying MDR is the overexpression of efflux transporters associated with chemotherapeutic drugs.

Severe acute respiratory syndrome virus 2 (SARS-CoV-2), the causative agent of coronavirus disease 19 (COVID-19), uses its spike (S) glycoprotein to enter host cells. The S glycoprotein consists of ...

Sialic acids, also referred to as neuraminic acids, are critical to glycoprotein bioavailability, function, stability, and metabolism. When present, these carbohydrates occupy terminal positions of ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Intravenous thrombolysis using recombinant ...

Glycoproteins and proteoglycans are two types of molecules that are composed of proteins and carbohydrates. They are both important components of the extracellular matrix, which is the network of ...

Platelet-neutrophil interactions contribute to vascular occlusion and tissue damage in thromboinflammatory disease. Platelet glycoprotein Ibα (GPIbα), a key receptor for the cell-cell interaction, is ...