Macrolactones—large ring lactones—are core components of many natural products and pharmaceutical agents. Traditional ...

Enantioselective α-alkylation of carbonyl is considered as one of the most important processes for asymmetric synthesis. Common alkylation agents, that is, alkyl halides, are notorious substrates for ...

The Rauhut–Currier (RC) reaction represents an efficient method for the construction of carbon–carbon bond in organic synthesis. However, the RC reactions involving allenoate substrates are very rare, ...

Taking advantages of intramolecular motion of D-A based aggregation-induced emission (AIE) molecular rotors and one-dimensional (1D) polymer fibers, highly sensitive optical fiber sensors that respond ...

A straightforward asymmetric strategy has led to the creation of elusive nitrogen stereocentres. The carefully designed ...

Distance markers: Polyprolines are relatively stiff polypeptides that can be used as intramolecular “rulers” to demonstrate MINFLUX optical resolutions. This image shows optically measured distances ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, No. 11 (May 23, 2000), pp. 5883-5888 (6 pages) Synaptotagmin I is a critical component of the synaptic ...

The structural basis of allosteric signaling in G protein-coupled receptors (GPCRs) is important in guiding design of therapeutics and understanding phenotypic consequences of genetic variation. The ...

Living cells resemble highly organized small towns - in addition to energy production, transportation systems, and construction, cells also require efficient waste disposal. Most proteins, which shape ...

Pioneering advances in ultrafast spectroscopy -- recognised, for one, by the award of the 2023 Nobel Prize in Physics -- have revolutionised our understanding of electron dynamics on the femtosecond ...