An expert discusses how nonstatin therapies serve as essential tools when patients can’t tolerate statins or need additional ...
Researchers have unveiled a new DNA-based therapy that silences the PCSK9 gene to lower cholesterol without statin side ...
In 1985, the Nobel Prize in Physiology or Medicine was awarded to Michael Brown and Joseph Goldstein for identifying the receptor that clears LDL particles from the bloodstream. High blood levels of ...
Preclinical data demonstrates proof-of-concept for EDIT-401 with ≥90% mean LDL-C reduction in non-human primates and mouse ...
Proprotein convertase subtilisin/kexin type-9 (PCSK9) is highly expressed in adult hepatocytes. PCSK9 binds to and promotes the degradation of the low-density lipoprotein (LDL) receptor, thereby ...
Alumni Endowed Professor of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University School of Medicine RNA viruses use a ...
Heart disease caused by damage to blood vessels is the leading cause of death worldwide. Arteries become clogged with fats and cholesterol when certain proteins in the body, known as lipoproteins, ...
Foods that raise cholesterol aren’t always as straightforward as they seem. Unfiltered coffee, ghee, tropical oils, refined carbohydrates and even high-sodium foods are sneaky culprits that can ...
Enlicitide is the first oral PCSK9 inhibitor to demonstrate statistically significant and clinically meaningful reductions in LDL-C compared to placebo in Phase 3 trials RAHWAY, N.J.--(BUSINESS WIRE)- ...
High levels of low-density lipoprotein (LDL) cholesterol can cause artery blockages and diseases like heart attacks and strokes. Further, it raises the risk of cardiovascular disease (CVD). Thickened ...
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