Gene structure and expression regulation mechanism are the research hotspots and focus of modern life sciences. The lac operon is a cluster of genes through which Escherichia coli catabolizes lactose.

This work is a continuation from another study previously published in this journal. Both the former and the present works are dedicated to investigating the bistable behavior of the lac operon in ...

Abstract: In this paper a Generalized Net (GN) model of the regulation of the lac operon in E. coli bacterium is presented. Prokaryotes, such the bacterium E. coli, have an efficient mechanism for ...

The lactose operon regulation in Escherichia coli is a primary model of phenotypic switching, reminiscent of cell fate determination in higher organisms. Under conditions of bistability, an isogenic ...

Repression of transcription of the Escherichia coli Lac operon by the Lac repressor (LacR) is accompanied by the simultaneous binding of LacR to two operators and the formation of a DNA loop. A ...

Hypothesis: the use of intergenic distances between adjacent genes in the same strand could be used to infer membership of the same operon in E. coli Python Scipy Kernel Density Estimation (KDE) was ...

The traditional view, as supported by Crasnier-Mednansky, places cAMP–CRP at the centre of CCR. This view is plausible, as it links glucose availability, the phosphorylation state of EIIA Crr and the ...