The myosin 2 family of molecular motors includes isoforms regulated in different ways. Vertebrate smooth-muscle myosin is activated by phosphorylation of the regulatory light chain, whereas scallop ...

Cardiac myosin is the molecular motor that drives heart contraction, powered by the energy-source ATP and through its interaction with actin tracks. Direct modulators of cardiac myosin function are ...

image: This graphic shows the proposed binding site for omecamtiv mecarbil to cardiac myosin S1. The ribbon diagram to the left shows the major features of the myosin S1 head. A spacefilling model of ...

The results discussed in the preceding paper indicate that A-band shortening in Limulus muscle is a thick filament response to activation that occurs largely by fragmentation of filament ends. To ...

A team of Yale and University of Pennsylvania researchers recently discovered that myosin, one of the proteins responsible for muscle contraction, can sense and adapt to different amounts of force.

Introduction: Inhibiting contractility by targeting cardiac myosin is an effective treatment for patients with hypertrophic cardiomyopathy (HCM). Aficamten (Afi), a second in class myosin inhibitor, ...

Researchers have shed light on the molecular mechanisms underlying hibernation, publishing their findings today as a Reviewed Preprint in eLife. Their research, in small and large hibernating mammals, ...