This important study presents a technically rigorous and carefully controlled analysis of the signalling potential of cancer-associated gain-of-function Notch alleles. The work is clearly presented, ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, No. 22 (Nov. 15, 1992), pp. 10563-10567 (5 pages) This report describes the identification of a negative ...

To study negative interactions between phytochromes, phytochrome B (phyB) overexpressor lines, the mutants phyA-201, phyB-4, phyB-5, phyD-1, phyA-201 phyB-5, phyA-201 phyD-1, and phyB-5 phyD-1 of ...

Negative feedback is a universal control mechanism that lets a system's output throttle its input. If an engine revs up, negative feedback tapers its power source. But if the engine slows down, it ...

Beijing Zhongke Journal Publising Co. Ltd. In summary, this work provides aninnovative strategy to ease CRISPR mutant identification and Cas9 transgene elimination using a single selection marker, ...

ORLANDO — Erythroferrone appeared to function as a negative regulator of osteoblast and osteoclast activity, and its loss can result in decreased bone mineral density in beta-thalassemia, according to ...

Late-onset depression, which first emerges in people aged 60 and over, is linked to a decline in the brain's executive functions that leads to repetitive, negative thought patterns a new study reveals ...