The puzzle seems impossible: take a three-billion-letter code and predict what happens if you swap a single letter. The code we’re talking about—the human genome—stores most of its instructions in ...

Non-coding DNA variants contribute to acute lymphoblastic leukemia (ALL) chemotherapy resistance. St. Jude Children's Research Hospital scientists have identified specific DNA variants in the ...

Despite progress in defining functional elements of noncoding DNA, it is still not fully understood. UCLA researchers, using an experiment that elucidated the function of tens of thousands of ...

Imagine the human genome as a string stretching out for the length of a football field, with all the genes that encode proteins clustered at the end near your feet. Take two big steps forward; all the ...

Noncoding elements in the genome, such as enhancers, silencers, and insulators, play important roles in gene expression and thus cellular behavior. Therefore, these elements may be of particular ...

Recent scientific breakthroughs have transformed the once-dismissed non-coding DNA, or “junk DNA,” into a targeted weapon ...

Scientists have found that non-coding 'junk' DNA, far from being harmless and inert, could potentially contribute to the development of cancer. Their study has shown how non-coding DNA can get in the ...

Schizophrenia is a severe neuropsychiatric disorder characterized by hallucinations, false beliefs about oneself or the world ...

(L to R) Co-first author Jackson Mobley, PhD, corresponding author Daniel Savic, PhD, and co-first author Kashi Raj Bhattarai, PhD, all of the St. Jude Department of Pharmacy and Pharmaceutical ...