Drugs that target opioid receptors sometimes have severe side effects. Thousands of people around the world die every day from overdoses involving opioids such as fentanyl. Researchers have taken a ...

Drugs that target opioid receptors can have serious adverse effects. Every day, thousands of people worldwide die as a result of opioid overdoses, including fentanyl. Opioid receptors are of major ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 16 (April 19, 2022), pp. 1-10 (10 pages) Allosteric modulators of G-protein-coupled receptors (GPCRs) ...

Leipzig [Germany], April 13 (ANI): Drugs that target opioid receptors can have serious adverse effects. Every day, thousands of people worldwide die as a result of opioid overdoses, including fentanyl ...

Scientists have known for decades that opioids relieve pain by binding to molecular switches in the brain called mu-opioid (pronounced “mew-opioid”) receptors. What they didn’t know — until now — was ...

Researchers at Rice University have revealed a previously unknown function of opioid receptors in the development of the enteric nervous system (ENS), often referred to as the “brain in the gut.” This ...

Opioids remain the most potent and effective pain relievers in medicine, but they’re also among the most addictive drugs that can halt a person’s ability to breathe during an overdose — which can be ...

A preclinical study led by a neuroscientist shows that dysregulated kappa-opioid receptors (KORs) in the brain's medial prefrontal cortex region (part of the frontal lobe) contribute to working memory ...

A worldwide team of experts investigated the molecular mechanisms of these active compounds. The study, conducted by Dr Matthias Elgeti, a biophysicist at Leipzig University, in partnership with ...

Despite the abuse potential of opioid drugs, they have long been the best option for patients suffering from severe pain. The drugs interact with receptors on brain cells to tamp down the body’s pain ...