Osteocytes, residing as 3-dimensionally (3D) networked cells in bone, are well known to regulate bone and mineral homeostasis and have been recently implicated to interact with cancer cells to ...

1 Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, United States 2 Medicine/Division of Nephrology, Indiana University School of Medicine, ...

Bone remodeling is a dynamic and continuous process involving three components: bone formation mediated by osteoblasts, bone resorption mediated by osteoclasts, and bone formation-resorption balancing ...

Osteocytes are differentiated osteoblasts that live within the bone matrix and are highly connected among themselves and with cells on the bone surface and the bone marrow The molecular and functional ...

Bone fragility increases with age as the result of the concurrent decline of bone mass, quality, and mechanosensitivity. While the coordinated decline of these behaviors remains unexplained, the role ...

Osteocytes originate from osteoblasts, which are responsible for bone formation, and function as regulators of bone tissue. They help maintain the tissue’s internal balance, a process called ...

A recent discovery could transform our understanding of bone health maintenance and pave the way for potential treatments for bone diseases, including osteoporosis. Researchers at the University of ...