Gene amplifications and deletions frequently have pathogenetic roles in cancer. 30,000 radiation-hybrid mapped cDNAs provide a genomic resource to map these lesions with high resolution. We developed ...

BUFFALO, N.Y. -- A multidisciplinary team of pharmaceutics and computer-science researchers at the University at Buffalo, one of very few teams in the nation applying DNA microarray technology in ...

In each type of cell, like a muscle cell or a skin cell, different genes are expressed (turned on) or silenced (turned off). If the cells that are turned on mutate, they could—depending on what role ...

Phase I and Pharmacologic Study of Oral ZD9331, A Novel Nonpolyglutamated Thymidylate Synthase Inhibitor, in Adult Patients With Solid Tumors ABSTRACT: Aberrant gene expression is critical for tumor ...

A standard Internet protocol that checks errors made during email transmissions has now inspired a revolutionary method to transform DNA microarray analysis, a common technology used to understand ...

DNA microarray chips enable the parallel investigation of a given sample concerning the presence and amount of specific DNA sequences within that sample. Whereas today such chips utilize optical ...

Paris, France, Friday 13 June 2008: A new DNA microarray chip can predict severe disability and remission in patients with rheumatoid arthritis (RA), as presented today at EULAR 2008, the Annual ...

An important question that arises when caring for patients referred for phase I clinical trials is, if one studied the patients’ tumors carefully enough, would there be targets in those patients’ ...