Europe PMC

Decarboxylation of pyruvate to acetaldehyde for ethanol production by hyperthermophiles.

Pyruvate decarboxylase (PDC encoded by pdc) is a thiamine pyrophosphate (TPP)-containing enzyme responsible for the conversion of pyruvate to acetaldehyde in many mesophilic organisms. However, no pdc ...
Europe PMC

Observation of thiamin-bound intermediates and microscopic rate constants for their interconversion on 1-deoxy-D-xylulose 5-phosphate synthase: 600-fold rate acceleration of ...

The thiamin diphosphate (ThDP)-dependent enzyme 1-deoxy-D-xylulose 5-phosphate (DXP) synthase carries out the condensation of pyruvate as a 2-hydroxyethyl donor with d-glyceraldehyde-3-phosphate ...
Nature

Crystal structures of the key anaerobic enzyme pyruvate:ferredoxin oxidoreductase, free and in complex with pyruvate

Oxidative decarboxylation of pyruvate to form acetyl–coenzyme A, a crucial step in many metabolic pathways, is carried out in most aerobic organisms by the multienzyme complex pyruvate dehydrogenase.
Scientific Research Publishing

A potential energy profile of the catalytic cycle of pyruvate decarboxylase ()

Dipartimento di Chimica, Università di Torino, Torino, Italy. Dipartimento di Chimica, Università di Torino, Torino, Italy;. Pyruvate decarboxylase (PDC, EC 4.1.1.1) is a 240 kDa protein [1] that ...
C&EN

Thiamin diphosphate: a mechanistic update on enzymic and nonenzymic catalysis of decarboxylation

Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to ...
C&EN

Decarboxylation-Triggered Polymer Deconstruction

Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article. Approaches for cleaving all-carbon polymer backbones often rely ...
Frontiers

Skeletal Muscle Pyruvate Dehydrogenase Phosphorylation and Lactate Accumulation During Sprint Exercise in Normoxia and Severe Acute Hypoxia: Effects of Antioxidants

Figure 1. Regulation of pyruvate dehydrogenase (PDH) activity in skeletal muscle. Pyruvate dehydrogenase complex (PDC) is regulated by phosphorylation and dephosphorylation by pyruvate dehydrogenase ...
Scientific Research Publishing

Solvent- and Catalyst-Free Microwave-Assisted Decarboxylation of Malonic Acid Derivatives ()

1 The Center of Chemical Research, UAEM, Cuernavaca, México. 2 SIGNA Civac S. A. de C. V., Jiutepec, México. The synthesis of carboxylic acid derivatives via malonic ester alkylation, hydrolysis, and ...