The enzymic activity of the mammalian pyruvate dehydrogenase complex is regulated by the phosphorylation of three serine residues (sites 1, 2 and 3) located on the E1 component of the complex. Here we ...

Barth syndrome (BTHS) is a rare genetic disorder due to mutations in the TAFAZZIN gene, leading to impaired maturation of cardiolipin and thereby adversely affecting mitochondrial function and energy ...

Pyruvate is the major product of glycolysis in pancreatic β-cells, and its ultimate metabolic fate depends on the relative activities of two enzymes. The first, pyruvate carboxylase (PC) replenishes ...

Introduction: There is no denying the clinical benefits of exogenous pyruvate in the treatment of pathological metabolic acidosis. However, whether it can prevent exercise physiological metabolic ...

After the injection of hyperpolarized [1-13 C]pyruvate, no change was observed in the heart rate of all animals [415 ± 31 beats per minute (bpm) before injection, 419 ± 31 bpm after injection], but ...

Pyruvate dehydrogenase (PDH) is a mitochondrial multiunit complex which catalyzes pyruvate oxidation (derived mainly from glucose) to acetyl-CoA which then enters tricarboxylic acid cycle. Its ...

The decarboxylation of pyruvate is a central reaction in the carbon metabolism of all organisms. It is catalyzed by the pyruvate:ferredoxin oxidoreductase (PFOR) and the pyruvate dehydrogenase (PDH) ...

Ethylene plays its essential roles in plant development, growth, and defense responses by controlling the transcriptional reprograming, in which EIN2-C-directed regulation of histone acetylation is ...