In budding yeast, most cytoplasmic mRNA turnover is initiated by deadenylation 1. These messages are then either decapped and subject to 5′ → 3′ decay 2,3 or degraded by the cytoplasmic exosome 4.

This fundamental study represents a real tour de force, demonstrating the impact of mutation on the mRNA decapping machinery. Accumulation of mRNAs in dcp2 mutants, is dependent both on the classical ...

Decapping of mRNA is a critical step in eukaryotic mRNA turnover, yet the proteins involved in this activity remain elusive in mammals. We identified the human Dcp2 protein (hDcp2) as an enzyme ...

The scavenger decapping enzyme hydrolyzes the protective 5′ cap structure on short mRNA fragments that are generated from the exosomal degradation of mRNAs. From static crystal structures and NMR data ...

We have examined the roles of yeast mRNA decapping-activators Pat1 and Dhh1 in repressing the translation and abundance of specific mRNAs in nutrient-replete cells using ribosome profiling, RNA-Seq, ...

It turns out there are three snoRNAs, U3, U8, and U13, that are transcribed by RNA Pol II and contain a m7G cap structure, which is later trimethylated in the cytoplasm, and reimported into the ...

EDC4 is a core component of processing (P)-bodies that binds the DCP2 decapping enzyme and stimulates mRNA decay. EDC4 also interacts with mammalian MARF1, a recently identified endoribonuclease that ...

A major pathway of eukaryotic messenger RNA (mRNA) turnover begins with deadenylation, followed by decapping and 5' to 3' exonucleolytic decay. We provide evidence that mRNA decapping and 5' to 3' ...

It turns out there are three snoRNAs, U3, U8, and U13, that are transcribed by RNA Pol II and contain a m7G cap structure, which is later trimethylated in the cytoplasm, and reimported into the ...

The 5′ end of eukaryotic mRNA is capped and methylated to protect mRNA from degradation and enhance protein synthesis. However, the cap can be removed from mRNA by decapping. We identified a recapping ...