Membrane receptors regulate numerous intracellular functions. However, the molecular underpinnings remain poorly understood because most receptors initiate multiple signaling pathways through distinct ...

T cells, also known as T lymphocytes, are the immune cells that drive the cellular immune response. There are several different types of T cells, each playing a distinct role. The functions of T cells ...

Oncogenic KRAS activation is responsible for the most common genetic subtype of lung cancer. Although many of the major downstream signaling pathways that KRAS engages have been defined, these ...

Dietary restriction reshapes CD8+ T cell metabolism by increasing ketone body–driven acetyl-CoA production, preventing ...

In therapeutic antibody development the fragment crystallizable (Fc) region is far more than just an antigen-binding aid; it's role is much larger, functioning as the antibody’s functional control ...

The crystal structure of the complex reveals an extensive interface between Pwl2 and OsHIPP43 (figure. 1). By modifying a plant intracellular immune receptor (NLR), researchers have developed a ...

Stimuli are changes in our environment that we respond to and are detected by receptors. Different receptors are sensitive to different stimuli (eg receptors in the eye are sensitive to light). A ...

Many cereal crops, such as wheat and barley, are prey to devastating fungal diseases caused by infection with so-called grass powdery mildews. A key battleground between the plants and the powdery ...