Endoplasmic reticulum–associated degradation (ERAD) is a cellular protein quality-control process that disposes of proteasomal substrates from the early secretory pathway. Recent work shows that the ...

Three families of polytopic proteases with membrane-embedded active sites have been discovered: site 2 proteases (S2Ps) are metalloproteases, presenilin-type aspartyl proteases are represented widely ...

Please could you tell us a little bit about rhomboid enzymes? Where are they found and what do they do? Rhomboid enzymes live in the cell’s membrane where their job is to cut the anchors of proteins, ...

Three commonly used nonsteroidal anti-inflammatory drugs alter the activity of enzymes within cell membranes, researchers have found. Their finding suggests that, if taken at higher-than-approved ...

Scientists have discovered a new mode of action for enzymes immersed in cellular membranes. Their experiments suggest that instead of recognizing and clipping proteins based on sequences of amino ...