Sterols inhibit their own synthesis in mammalian cells by blocking the vesicular endoplasmic reticulum-to-Golgi transport of sterol regulatory element-binding protein (SREBP) cleavage-activating ...

The polytopic membrane protein SCAP transports sterol regulatory element-binding proteins (SREBPs) from the endoplasmic reticulum (ER) to the Golgi, thereby activating cholesterol synthesis.

Moreover, we observed decreased SCAP levels in PKM2 KO cells (Fig 2G), suggesting that the reduction of nuclear SREBP1 and decreased expression of SREBP1 target genes may be attributed to the loss of ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The pyruvate kinase M2 isoform (PKM2) is ...