The improvement of proteins and pathways for biotechnology and biomedical applications can be achieved by directed evolution 1,2. Directed evolution typically uses iterative rounds of selection or ...

Figure 3: CPR evolved 5-hydroxy-L-tryptophan–using tRNA synthetase and optimized tRNA. The evolution of transcription and translation machinery suggests that CPR can evolve enzymes and RNAs that are ...

Abstract: Logic replication is known to be an effective technique to reduce the number of cut nets in partitioned circuits. A new replication model called functional replication is particularly useful ...

Abstract: Previous results show that node replication can be used to reduce the number of cut edges substantially in a partitioned circuit. The node replication approach is particularly useful for ...

Compartmentalized partnered replication (CPR) is an emulsion-based directed evolution method based on a robust and modular phenotype-genotype linkage. In contrast to other in vivo directed evolution ...

Biocircuit modeling sometimes requires explicit tracking of a self-replicating DNA species. The most obvious, straightforward way to model a replicating DNA is structurally unstable and leads to ...

This software facilitates the process of designing and documenting electronic circuits by allowing engineers to create and manage schematic diagrams digitally. Schematic capture software, also known ...

Dr Hu Han (Former SCSE Research Fellow), Mr Huang Jian (Former SCSE Research Assistant) and Associate Professor Wen Yonggang (Associate Dean – Research, College of Engineering, NTU Singapore), ...