The issue of one-sided versus two-sided hypothesis testing in clinical trial analyses has been the subject of debate in the medical and statistical literature. 1–4 This design consideration represents ...

Advances in high-throughput biology and computer science are driving an exponential increase in the number of hypothesis tests in genomics and other scientific disciplines. Studies using current ...

Sample size and power calculations are available for one-sample and two-sample paired and independent designs where the proposed analysis is hypothesis testing of a mean or means via a t-test. These ...