Nature

HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

Figure 1: HDAC6 rescues degeneration in flies with proteasome impairment and in a fly model of SBMA that exhibits impaired UPS function. Figure 2: Induction of compensatory autophagy in flies with ...
Nature

Sensitive detection of proteasomal activation using the Deg-On mammalian synthetic gene circuit

The ubiquitin proteasome system (UPS) has emerged as a drug target for diverse diseases characterized by altered proteostasis, but pharmacological agents that enhance UPS activity have been ...