Living with Sickle Cell Disease means that every treatment comes with its own side effects. Today, we will focus on the dangers of blood exchange or transfusion and the risk of iron overload. In ...

Saturation of TfR1 leads to the dissociation of Hfe and the binding of the alter to the TfR2, which in turn influences the binding of BMP6 to its receptors on the membrane. Increased liver iron ...

A 50-year-old man presented with persistent hyperferritinemia (serum ferritin, 1500–2100 ng/ml; reference range [RR], 30–400 ng/ml), elevated serum iron level (300 µg/dl; RR, 60–170 µg/dl), and ...

Beta-thalassemia, also known as β-thalassemia is a genetic disorder marked by reduced or absent beta chain synthesis of hemoglobin, leading to ineffective erythropoiesis and severe anemia. Patients ...

BMP, bone morphogenetic protein; BMPR, bone morphogenetic protein receptor; HAMP, hepcidin; HFE, hereditary hemochromatosis protein; HJV, hemojuvelin; Holo-Tf, holo ...

Patients with serum ferritin levels higher than 1000 μg/L show a 91% increased risk for any fracture, with a doubled risk for vertebral and humerus fractures compared with those without iron overload.

The clinical introduction of hepcidin25 (Hep25) has led to a more detailed understanding of its relationship with ferroportin (FP) and divalent metal transporter1 in primary iron overload syndromes ...