While synthetic siRNA libraries are powerful tools for functional genomic screens, off-target effects mediated by siRNA seed interactions with the 3' UTR of unintended targets can result in false ...

Guava Technologies, Inc. presented at the recent Molecular Targets & Cancer Therapeutics Symposium information on their recent advancements that describe an experimental methodology and the new Guava® ...

低分子量GTPasesのRhoファミリーは、細胞運動の調節に重要であることがわかっている。Cellに発表されたChris Marshallらの最近の論文では、RacおよびRhoの活性化の違いによって、細胞のとる運動の種類が決まることが明らかにされている。 個々の腫瘍細胞は ...

Liver injury in chemotherapy (CT)-treated breast, colorectal, and lung cancer (CA) patients (Pts) using automated health data. This is an ASCO Meeting Abstract from the 2011 ASCO Annual Meeting I.

LAFAYETTE, Colo.-- The Genome-Wide RNAi Global Initiative (RNAi Global), an alliance of Dharmacon, Inc., and 14 leading international research centers pioneering the use of whole-genome RNAi screening ...

Over the past several years, RNAi screening went through a period of technology development aimed at gaining a better understanding of its advantages and limitations, and there is now an “established ...

New Transfection Systems Tackle Delivery Issues and Off-Target Effects Will RNAi-based therapeutics provide the next class of blockbuster drugs? If pharma’s acquisition spree of companies with ...