Scientists led by a team at the Medical Research Council (MRC) Mitochondrial Biology Unit, University of Cambridge, have worked out how a molecular machine found in mitochondria—the “powerhouses” of ...

Pyruvate dehydrogenase plays a critical role in how cells produce energy. The reaction it carries out is the first step in converting pyruvate, which the body derives from food, to acetyl-CoA, a fuel ...

Pyruvate is produced by glycolysis, a process in which carbohydrates are broken down to create energy. Calcium pyruvate is a popular supplement that many people use primarily for its purported weight ...

The Food and Drug Administration (FDA) has accepted for Priority Review the New Drug Application for SL1009 (sodium dichloroacetate oral solution) for the treatment of pyruvate dehydrogenase complex ...

A team of researchers led by Tobias Erb at the Max Planck Institute for Terrestrial Microbiology in Marburg has succeeded in developing a new enzyme. The 'lactyl-CoA mutase' can efficiently convert a ...

Malaria that is caused by Plasmodium falciparum is a significant global health problem. Genetic characteristics of the host influence the severity of disease and the ultimate outcome of infection, and ...

Few building blocks in cellular metabolism are as central and versatile as acetyl-coenzyme A (acetyl-CoA). As a product of many CO 2 fixation pathways, its utilization in the cell determines how much ...