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  1. Disease - Wikipedia

    A disease may be caused by external factors such as pathogens or by internal dysfunctions. For example, internal dysfunctions of the immune system can produce a variety of different …

  2. Disease | Definition, Types, & Control | Britannica

    Oct 30, 2025 · Disease is any harmful deviation from the normal structural or functional state of an organism. It generally is associated with certain signs and symptoms.