A fraction of erythrocytes appear as target cells in stained blood smears in sickle cell disease, due to a inheritance of the hemoglobin variant Hb S, polymerizing upon deoxygenation.

When a patient presents with symptoms suggestive of a crisis—such as severe pain, fatigue, or signs of organ ischemia—a peripheral smear can provide immediate visual confirmation of the …

15 Lún 2025 · The histology of sickle cell disease (SCD) involves examination of peripheral blood smears and changes across organ systems, including the spleen, kidneys, bone, liver, and lungs.

28 Feabh 2025 · Sickle cell disease (SCD) is an inherited group of disorders characterized by the presence of hemoglobin S (Hb S), either from homozygosity for the sickle mutation (Hb SS) or …

1 Aib 2009 · Peripheral smear from a patient with sickle cell disease illustrates the spectrum of RBC findings in this disorder including sickle cells, polychromatophilic RBCs, target cells, and …

Sickle-shaped red blood cells cause vaso-occlusion and are prone to hemolysis, leading to severe pain crises, organ ischemia, and other systemic complications. Acute exacerbations (crises) …

Peripheral smear from a patient with sickle cell disease illustrates the spectrum of RBC findings in this disorder including sickle cells, polychromatophilic RBCs, target cells...