Nov 4, 2025 · This review delineates the mechanistic basis of cytokine storm-driven injury in sepsis, explores evolving immunomodulatory therapies, and evaluates emerging diagnostic …

In this review, we will detail the mechanisms leading to the induction of the cytokine storm during sepsis and describe how and what cytokines are released and how they may contribute to cell …

Jul 9, 2025 · This study reported a significant reduction in pro-inflammatory cytokines such as TNF-α, IL-6, and IL-1β, which are known to drive the cytokine storm in sepsis.

Current concepts of sepsis pathogenesis focus on an excessive host inflammatory response to infection that is mediated by elevated cytokine levels, also known as ‘cytokine storm’ or …

Nov 7, 2025 · IL-6, a key pro-inflammatory cytokine in sepsis, drives the “cytokine storm.” Elevated IL-6 levels are not only associated with sepsis severity but also predict a higher risk of ARDS …

While these proteins typically regulate inflammation, an overly aggressive immune response can result in a cytokine storm, leading to tissue damage, organ failure, and, ultimately, death.

Nov 5, 2025 · This review aims to critically examine the multifaceted roles of cytokines in the pathogenesis of sepsis, with a particular focus on the molecular underpinnings of cytokine …

Jan 8, 2024 · These proteins help control inflammation, but when the immune system responds more aggressively than it should, it can release a “cytokine storm” on all tissues, causing tissue …

This review systematically summarizes the cellular and molecular mechanisms underlying cytokine storm, emphasizing the roles of TNF-α, IL-1β, IL-6, and inflammasome activation.

Nov 30, 2021 · This review focuses on pathophysiological mechanisms underlying cytokine storm induction and progression induced by pathogenic invasive infectious diseases. Strategies for …