Antibody–drug conjugates: Recent advances in linker chemistry
Antibody–drug conjugates (ADCs) are gradually revolutionizing clinical cancer therapy. The antibody–drug conjugate linker molecule determines both the efficacy and the adverse effects, …
CPHI 2025: linker innovation paves the way for a wave of new ADCs
2 days ago · Antibody-drug conjugate (ADC) developers say innovations to linkers, the proteins bridging antibodies to their therapeutic payloads, are opening the door to more stable, selective …
Legumain-Cleavable Top1i Antibody-Drug Conjugates without Self ...
3 days ago · Virtually all antibody-drug conjugates employ a cleavable linker that is attached to a self-immolative spacer element. The linker and self-immolative spacer are widely known to …
Linker-GPT: design of Antibody-drug conjugates linkers with …
Jul 1, 2025 · Antibody-drug conjugates (ADCs) 1, 2 are innovative therapeutic agents that combine monoclonal antibodies with cytotoxic drugs via chemical linkers 3, enabling precise and …
What Are Antibody–Peptide Conjugates (APCs) Drugs and Their ...
2 days ago · What Are Antibody–Peptide Conjugates (APCs) APC typically consists of an antibody, a peptide, and a linker. In February 2024, Amgen published Phase I clinical results in …
Antibody–drug conjugates: Recent advances in linker chemistry
Dec 1, 2021 · Antibody–drug conjugates (ADCs) are gradually revolutionizing clinical cancer therapy. The antibody–drug conjugate linker molecule determines both the efficacy and the …
An Introduction to Linkers in Antibody-Drug Conjugates (ADCs)
Sep 30, 2024 · Antibody-drug conjugates (ADCs) are “biological bullets” that combine cytotoxic drugs (payloads) with antibodies through “linkers.” ADCs consist of five key elements: target, …
Lysosomal-Cleavable Peptide Linkers in Antibody–Drug Conjugates
Antibody–drug Conjugates (ADCs) are a powerful therapeutic modality for cancer treatment. ADCs are multi-functional biologics in which a disease-targeting antibody is conjugated to an …
Technical Support Center: Optimization of Linker Chemistry for …
Author : BenchChem Technical Support Team. Date : November 2025 Compound of interest: Val-Ala-PABC-Exatecan trifluoroacetate The Compound Cat. No.: B12371944 This technical …
Chemical Linkers in Antibody–Drug Conjugates (ADCs)
Dec 15, 2021 · Chemical Linkers in Antibody–Drug Conjugates aims to shine a detailed light on the various key attributes of chemical linkers in ADCs, for drug-to-antibody ratio, for stability, for …
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