Antibody–drug conjugates (ADCs) are gradually revolutionizing clinical cancer therapy. The antibody–drug conjugate linker molecule determines both the efficacy and the adverse effects, …

3 days ago · Antibody-drug conjugate (ADC) developers say innovations to linkers, the proteins bridging antibodies to their therapeutic payloads, are opening the door to more stable, selective …

4 days ago · Virtually all antibody-drug conjugates employ a cleavable linker that is attached to a self-immolative spacer element. The linker and self-immolative spacer are widely known to …

Jul 1, 2025 · Antibody-drug conjugates (ADCs) 1, 2 are innovative therapeutic agents that combine monoclonal antibodies with cytotoxic drugs via chemical linkers 3, enabling precise and …

3 days ago · What Are Antibody–Peptide Conjugates (APCs) APC typically consists of an antibody, a peptide, and a linker. In February 2024, Amgen published Phase I clinical results in …

Sep 30, 2024 · Antibody-drug conjugates (ADCs) are “biological bullets” that combine cytotoxic drugs (payloads) with antibodies through “linkers.” ADCs consist of five key elements: target, …

1 day ago · Antibody Drug Conjugates (ADCs) are targeted therapies that combine an antibody, a potent drug, and a linker. They precisely deliver chemotherapy to cancer cells, reducing …

Aug 2, 2025 · Inspired by the "magic bullet" concept proposed over a century ago, antibody-drug conjugates (ADCs) are developed to enhance cancer therapy by linking monoclonal antibodies …

Dec 1, 2021 · Antibody–drug conjugates (ADCs) are gradually revolutionizing clinical cancer therapy. The antibody–drug conjugate linker molecule determines both the efficacy and the …

An antibody–drug conjugate consists of three components: [34][35] Antibody - targets the cancer cell surface and may also elicit a therapeutic response. Payload - elicits the desired therapeutic …