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  1. Adding Tucatinib to First-line Maintenance Therapy Delayed Disease ...

    3 days ago · The trial enrolled 654 patients with HER2-positive advanced breast cancer who had completed four to eight cycles of induction chemotherapy plus trastuzumab and pertuzumab, without …

  2. HER2CLIMB-05: A Phase 3 Study of Tucatinib Versus Placebo in ...

    3 days ago · Conclusions: Tucatinib addition to trastuzumab and pertuzumab demonstrated improvement in PFS with no new safety signals identified and may be an option for 1L maintenance …

  3. Enhertu/Perjeta Combo Enhances Quality of in HER2+ Advanced Breast Cancer

    1 day ago · The DESTINY-Breast09 trial compared Enhertu plus Perjeta to the standard-of-care regimen of trastuzumab (Herceptin), Perjeta, and taxane as first-line therapy for patients with HER2-positive …

  4. Adding Tucatinib (Tukysa) to First-Line Maintenance Therapy Improves …

    2 days ago · Results from the phase 3 HER2CLIMB-05 trial show that adding tucatinib (Tukysa) to first-line maintenance therapy with trastuzumab (Herceptin) and pertuzumab (Perjeta) in patients with …

  5. Adding tucatinib to first-line maintenance therapy delays disease ...

    2 days ago · Adding tucatinib (Tukysa) to first-line maintenance therapy with trastuzumab (Herceptin) and pertuzumab (Perjeta) delayed disease progression in patients with HER2-positive metastatic …

  6. TUKYSA Added to First-Line Maintenance Therapy Extends Median

    3 days ago · TUKYSA is approved in combination with trastuzumab and capecitabine to treat adults with HER2-positive advanced unresectable or metastatic breast cancer, including patients with brain …

  7. Tucatinib Plus Trastuzumab/Pertuzumab Prolongs PFS in HER2 …

    2 days ago · As such, there is an unmet need for developing more effective first-line maintenance treatments in HER2-positive metastatic breast cancer.

  8. Tucatinib combo improves PFS in breast cancer subset - Healio

    2 days ago · SAN ANTONIO — The addition of tucatinib to first-line trastuzumab plus pertuzumab delayed disease progression among a cohort of women with HER2-positive metastatic breast cancer …

  9. Pfizer makes first-line case for Tukysa in breast cancer

    1 day ago · Pfizer's Tukysa looks poised to find a new role as first-line maintenance therapy for HER2-positive metastatic breast cancer.

  10. Trastuzumab (Herceptin) for Metastatic Breast Cancer Treatment

    Sep 17, 2025 · Find data from studies on trastuzumab (Herceptin) and metastatic breast cancer treatment.