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In most cells, checkpoints in the cell cycle prevent a cell from entering one phase if the events of the preceding phase have not been completed. At the G1 checkpoint, the cell checks for damaged DNA. Arrest at the G1 checkpoint allows repair of the damage to take place before the cell enters S phase, where the damaged DNA would be replicated. The S-phase checkpoint provides continual monitoring of the integrity of DNA to ensure that damaged DNA is repaired before it is replicated. In addition,
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