G Protein-coupled Receptors
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Figure 11.12 cAMP as a second messenger in a G proteinsignaling pathway.First messenger(signaling moleculesuch as epinephrine)G protein-coupledreceptor (GPCR)1G protein23GTP1 First messenger binds toATP4GPCR, activating it.CAMP2 Activated GPCR binds to Gprotein, which is then bound by GTP,activating the G protein.3 Activated G protein/GTP binds to5AdenylylcyclaseSecondmessengerProteinkinase Aadenylyl cyclase. GTP is hydrolyzed,activating adenylyl cyclase.Cellular responses4 Activated adenylyl cy
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